ESPEN 2022 Abstract Submission

Topic: Nutritional epidemiology

Abstract Submission Identifier: ESPEN22-ABS-1556

SERUM N-6 POLYUNSATURATED FATTY ACIDS AND EXERCISE-INDUCED MYOCARDIAL ISCHEMIA

H. Esmaili^*, ¹, B. Tajik ¹, T. P. Tuomainen ¹, J. K. Virtanen ¹

¹Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

Rationale: N-6 polyunsaturated fatty acids (PUFA), especially linoleic acid (LA), have been inversely associated with coronary heart disease (CHD). However, mechanisms underlying these associations are not fully known. We investigated the associations of the serum concentrations of total n-6 PUFA, LA, arachidonic acid (AA), gamma-linolenic acid (GLA), and dihomo -gamma-linolenic acid (DGLA), with the odds for myocardial ischemia during exercise, a predictor of future cardiac events

Methods: 2840 men from the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD), aged 42-60 years. All participants performed a maximal symptom-limited exercise stress test in the morning, by using an electrically braked bicycle ergometer. The criteria for ischemia were horizontal ECG during exercise or down-sloping ST depression ≥1.0 mm at 80 ms after J point or any ST depression of >1.0 mm at 80 ms after J point. Multivariable-adjusted logistic regression was used to assess the odds ratio (OR) for exercise-induced myocardial ischemia in quartiles of serum n-6 PUFA concentrations.

Results: Men in the highest vs., the lowest serum total n-6 PUFA concentration had 22% lower odds for exercise-induced myocardial ischemia (multivariable-adjusted extreme-quartile OR 0.78, 95%CI 0.62-1.00, P-trend across quartiles= -0.04). Inverse associations were also found with serum LA and AA concentrations (OR 0.79, 95%CI 0.61-1.01, P-trend= -0.05 and OR 0.58, 95%CI 0.44-0.77, P-trend<0.00,1 respectively). Serum GLA and DGLA concentrations were not associated with exercise-induced myocardial ischemia.

Conclusion: Higher serum concentrations of total n-6 PUFA, LA, and AA were associated with lower odds for myocardial ischemia during exercise.

Disclosure of Interest: None Declared

Keywords: Exercise myocardial ischemia, maximal oxygen uptake test, n-6 polyunsaturated fatty acids, population study