ESPEN 2022 Late Breaking Abstracts

Topic: Nutritional assessment

Abstract Submission Identifier: ESPEN22-LB-2139

EVALUATION OF THE EFFECTS OF A NEW READY TO DRINK, PLANT-BASED ORAL NUTRITIONAL SUPPLEMENT (ONS) IN ADULT COMMUNITY PATIENTS AT RISK OF DISEASE-RELATED MALNUTRITION (DRM).

M. Delsoglio^*, ¹, C. Griffen ¹, R. Syed ², T. Cookson ³, H. Saliba ³, A. Vowles ³, S. Davies ⁴, N. Willey ⁴, J. Thomas ⁴, N. Millen ⁵, N. Odeh ⁵, J. Longstaff ⁵, N. Westran ⁶, M. Phillips ⁶, L. Allan ⁶, H. Offer ⁷, C. Howell ⁷, M. Sanders ⁷, K. Gaffigan ⁷, K. Garrett ⁷, S. Foster ⁸, A. Salt ⁸, E. Carter ⁸, S. Moore ⁸, N. Bergin ⁹, J. Roper ¹⁰, J. Alvarez ¹⁰, C. Voss ¹¹, T. Connolly ¹¹, C. MacDonald ¹¹, T. Trower ¹¹, D. Sills ¹², J. Baxter ¹³, R. Manning ¹³, K. Voas ¹⁴, S. Richardson ¹⁵, A.-M. Hurren ¹⁵, D. Murphy ¹⁶, S. Blake ¹⁶, P. McArdle ¹⁷, S. Walsh ¹⁷, L. Booth ¹⁷, L. Albrich ¹⁸, S. A. Maguire ¹⁸, J. Allison ¹⁸, J. McClorey ¹⁹, S. Brook ²⁰, R. Capener ¹, G. P. Hubbard ¹, R. J. Stratton ²¹

¹Medical Affairs, Nutricia Ltd, Trowbridge, ²Preston Hill Surgery, Preston Hill, ³Trowbridge Health Centre, Trowbridge, ⁴West Walk Surgery, Bristol, ⁵Cowplain Family Practice, Waterlooville, ⁶Royal Surrey County Hospital, Surrey, ⁷Thorpe Health Centre, Norwich, ⁸North Tyneside District General Hospital, Tyne and Wear, ⁹Airedale General Hospital, Keighley, ¹⁰Warden Lodge Medical Practice, Waltham Cross, ¹¹Rowden Hill Surgery, Chippenham, ¹²City Hospital Campus, Nottingham, ¹³Kings Cross Hospital, Dundee, ¹⁴Glan Clwyd Hospital, Rhyl, ¹⁵James Alexander Family Practice, Hull, ¹⁶Honiton Surgery, Honiton, ¹⁷Birmingham Community Nutrition, Birmingham, ¹⁸Yeovil District Hospital, Yeovil, ¹⁹Mountainhall Treatment Centre, Dumfries, ²⁰Locala CIC, Huddersfield, ²¹University of Southampton, Southampton, United Kingdom

Rationale: The use of oral nutritional supplements (ONS) has been shown to be effective for managing disease-related malnutrition (DRM). The aim of this one-arm multi-centre intervention study was to evaluate the effects of a plant-based ONS in community adult patients at risk of DRM.

Methods: A ready to drink, plant-based, nutritionally complete ONS (300kcal, 12g protein: 1.5kcal/ml, Nutricia Ltd., UK), was prescribed (≥1/day) alongside dietary advice for 28days, to adult community-based patients with multiple diagnoses at risk of DRM.  Body weight, BMI, ‘MUST’ score¹, dietary intake (24h dietary recall), and appetite (Simplified Nutritional Appetite Questionnaire (SNAQ)²) were assessed at baseline and intervention end. Intention to treat data analysis was performed.

Results: Twenty-four patients (age:59±18years; BMI:18.9±3.3kg/m²) were included. High risk of malnutrition¹ reduced from 20 to 16 patients (p=0.046) with a significant increase in body weight (+0.6±1.2kg, p=0.02) and BMI (+0.2±0.5kg/m², p=0.03) at intervention end. Total energy intake significantly increased (from 1204±575kcal/day to 1576±404kcal/day, +371±457kcal/day, p=0.001), as well as protein intake (from 44+21g/day to 58±17g/day, +14±39g/day, p=0.03). Appetite (from 11.3±3.0 to 11.9±3.5, p=0.13) and food-only energy intake (from 1078±368kcal/day to 1208±319kcal/day, +130±325 kcal/day; p=0.43) were maintained throughout the study.

Conclusion: The intervention with a new ready to drink, plant-based ONS alongside dietary advice significantly improved clinical outcomes in community-based patients at risk of DRM. Further investigation is required to ascertain the clinical benefits of using a plant-based supplement in the management of patients with malnutrition.

References: 1.Frank M, Sivagnanaratnam A, Bernstein J Nutritional assessment in elderly care: a MUST! BMJ Open Quality 2015;4:u204810.w2031. 2.Wilson MM, et al. Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. American Journal of Clinical Nutrition. 2005;82(5):1074-81.

Disclosure of Interest: M. Delsoglio Other: Nutricia employee, C. Griffen Other: Nutricia employee, R. Syed: None Declared, T. Cookson: None Declared, H. Saliba: None Declared, A. Vowles: None Declared, S. Davies: None Declared, N. Willey: None Declared, J. Thomas: None Declared, N. Millen: None Declared, N. Odeh: None Declared, J. Longstaff: None Declared, N. Westran: None Declared, M. Phillips: None Declared, L. Allan: None Declared, H. Offer: None Declared, C. Howell: None Declared, M. Sanders: None Declared, K. Gaffigan: None Declared, K. Garrett: None Declared, S. Foster: None Declared, A. Salt: None Declared, E. Carter: None Declared, S. Moore: None Declared, N. Bergin: None Declared, J. Roper: None Declared, J. Alvarez: None Declared, C. Voss: None Declared, T. Connolly: None Declared, C. MacDonald: None Declared, T. Trower: None Declared, D. Sills: None Declared, J. Baxter: None Declared, R. Manning: None Declared, K. Voas: None Declared, S. Richardson: None Declared, A.-M. Hurren: None Declared, D. Murphy: None Declared, S. Blake: None Declared, P. McArdle: None Declared, S. Walsh: None Declared, L. Booth: None Declared, L. Albrich: None Declared, S. A. Maguire: None Declared, J. Allison: None Declared, J. McClorey: None Declared, S. Brook: None Declared, R. Capener Other: Nutricia employee, G. Hubbard Other: Nutricia employee, R. Stratton Other: Nutricia employee

Keywords: disease related malnutrition, oral nutritional supplement, plant-based diet, plant-based oral nutritional supplement