ESPEN 2022 Late Breaking Abstracts

Topic: Nutrition and chronic disease

Abstract Submission Identifier: ESPEN22-LB-2119

NURITIONAL STATUS AND HUMERAL RESPONSE TO SARS-COV-2 VACCINE IN HEMODIALYSIS PATIENTS

M. Jacobson Naftali^*, ¹, O. Azoulay ¹, S. Frishman ¹, L. Godny ¹, T. Agur ², B. Rozen-Zvi ²

¹Nutrition Unit, ²Nephrology & Hypertension, Rabin Medical Center, Petaḥ Tikva, Israel

Rationale: Patients in hemodialysis are at risk for poor nutritional status. Here we aimed to investigate whether poor nutritional status while receiving the first vaccine dose was associated with impaired response to the SARS-COV-2 vaccine

Methods: This was a retrospective single-center study that included 116 adult hemodialysis patients who are treated in the two hospital-based dialysis units of RMC (Rabin Medical Center) . All The patients had been vaccinated with two doses of BNT162b2 vaccine, 21 days apart. Demographic data and blood tests results were collected from the medical records Antibody response was assessed by quantitative measurement of IgG antibodies against the Spike protein (anti-S antibodies) by the SARS-CoV-2 IgG II Quant (Abbott©) assay

Nutritional status was assessed using Malnutrition Inflammation Score (MIS) evaluated around the vaccination of the first dose.

Results: We recruited 116 patients. Of which 39 (34%) were females, the average age was 76.8 years and 56.8% had diabetes mellitus. Moderate to Severe malnutrition (MIS>5) was detected in 42/116 (36%) patients.

Moderate to severe malnourished patients had decreased anti-S antibodies level compared to well-nourished patients with median log-transformed antibodies [3.06 (2.33-3.43) vs. 3.26 (2.84-3.78), respectively p= 0.045]. In a multivariate analysis, adjusted for age, gender, KT/V, and history of diabetes, MIS remained significantly inversely associated with COVID-19 antibodies response (B -0.46, P=0.041).

Conclusion: Moderate to severe malnutrition is associated with reduced humoral response to SARS-COV-2 vaccination in hemodialysis patients.

References: 1.Ikizler TA, Burrowes JD, Byham-Gray LD, Campbell KL, Carrero JJ, Chan W, Fouque D, Friedman AN, Ghaddar S, Goldstein-Fuchs DJ, Kaysen GA, Kopple JD, Teta D, Yee-Moon Wang A, Cuppari L. KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update. Am J Kidney Dis. 2020 Sep;76(3 Suppl 1): S1-S107. doi: 10.1053/j.ajkd.2020.05.006

2. Agur T, Ben-Dor N, Goldman S, Lichtenberg S, Herman-Edelstein M, Yahav D, Rozen-Zvi B, Zingerman B. Antibody response to mRNA SARS-CoV-2 vaccine among dialysis patients - a prospectivecohort study. Nephrol Dial Transplant. 2021 Apr 11: gfab155. doi: 10.1093/ndt/gfab155

Disclosure of Interest: None Declared

Keywords: Hemodialysis patients , Humoral response , Malnutrition Inflammation Score, SARS-COV-2.