ESPEN 2011 Late breaking abstract submission

Topic: Late Breaking Abstract

Abs n°:ESPEN11-2095

Abs Title: OXIDATION AND ABSORPTION OF GLUCOSE AND FRUCTOSE COMPONENT INGESTED AS A LOW GLYCEMIC SUCROSE-ISOMER ISOMALTULOSE (PALATINOSE) IN HUMAN.

Y. Urita ^1,*T. WATANABE ¹I. TAKEMOTO ¹H. TANAKA ¹N. SHIMADA ¹H. NAKAJIMA ¹H. TONOUCHI ²M. Uchida ²H. Sasaki ²J. Kashimura ³M. Sugimoto ¹

¹Department of General Medicine and Emergency Care, TOHO UNIVERSITY, Tokyo, ²Food Science Institute, Division of Research and Development, Meiji Dairies Corporation, Odawara, ³Mitsui Sugar Co.Ltd, Tokyo, Japan

Rationale: Isomaltulose (palatinose) is composed of alpha-1,6-linked glucose and fructose, suitable as a non-cariogenic sucrose replacement. It has been less clear how the monosaccharides glucose and fructose are metabolized when consumed together as the disaccharide palatinose. The aim of this study is to investigate the acute metabolism of the monosaccharide components of palatinose. 

Methods: A total of 58 consecutive patients who underwent diagnostic upper endoscopy were recruited. At the end of endoscopy, a tip of endoscope was placed to the second part of the duodenum and 5 ml of water containing 100 mg of [1-¹³C]glucose and [1-¹³C]fructose, or 200mg of ¹³C-isomaltulose ([1-¹³C^glu]palatinose or [1-¹³C^fru] palatinose) was sprayed into the duodenum. Breath samples were taken at 10 min-intervals for 90 min.

Results: The ¹³CO2 excretion rose more sharply after ingestion of [1-¹³C^fru]palatinose than after ingestion of [1-¹³C^glu]palatinose and remained higher throughout the study period. ¹³CO2 excretion levels were significantly higher in the [1-¹³C]fructose breath test between 10 and 30 min, compared to in the [1-¹³C]glucose. 13CO2 excretion was significantly higher after ingestion of [1-¹³C^fru]palatinose than that after ingestion of [1-¹³C]fructose and remained higher throughout the study period. ¹³CO2 excretion was significantly higher after ingestion of [1-¹³C]glucose than after ingestion of [1-¹³C^glu]palatinose and the differences between the two 13CO2 excretion curves were getting greater with time. 

Conclusion: In conclusion, fructose component of palatinose might have a sparing effect on absorption and oxidation of glucose component and causes a gradual increase in blood glucose after ingestion of palatinose.

Disclosure of Interest: None Declared

Keywords: Isomaltulose・Low glycemic index・Glucose・Fructose・Breath test