AB0035

ASSOCIATIONS BETWEEN ENOS POLYMORPHISMS AND SUSCEPTIBILITY TO SYSTEMIC LUPUS ERYTHEMATOSUS: A META-A

Y. H. Lee ^1,*S. J. Choi ¹J. D. Ji ¹G. G. Song ¹

¹Korea University Medicial Center, Seoul, Korea, Republic Of

Background: Genetic factors may play a role in the development of systemic lupus erythematous (SLE), and endothelial nitric oxide synthase (eNOS) polymorphisms have been associated with SLE.

Objectives: The aim of this study was to determine whether eNOS polymorphisms confer susceptibility to SLE and lupus nephritis (LN).

Methods: A meta-analysis was conducted on the associations between the 4b/a, G894T, and C786T polymorphisms of eNOS and SLE and LN using; 1) the allele contrast, 2) the recessive, 3) the dominant, and 4) the additive models.

Results: A total of 8 studies, which included 1297 cases and 1214 controls, were included in the meta-analysis. Meta-analysis showed no association between SLE and the 4b/a polymorphism in all study subjects. Stratification by presence of LN indicated a significant association between the a allele and the aa+ab genotype of the 4b/a polymorphism and LN in SLE patients (OR = 2.125, 95% CI = 1.289–3.054, p = 0.003; OR = 2.655, 95% CI = 1.509–4.671, p = 0.001). No association was found between SLE and the G894T polymorphism using the allelic, recessive, or dominant, or additive models. Meta-analysis of the T786C polymorphism showed a tendency of an association between the TT genotype and SLE (OR = 1.220, 95% CI = 1.000–1.489, p = 0.050), and meta-analysis of the TT vs. CC genotype of the C786T polymorphism in group in H-W equilibrium revealed a significant association between the TT genotype and SLE (OR = 1.643, 95% CI = 1.021–2.644, p = 0.041).

Conclusions: This meta-analysis of published studies shows that the 4b/a polymorphism may be associated with the development of LN, and the C786T polymorphism may be associated with SLE susceptibility.

Disclosure of Interest: None Declared