ESPEN 2012 - Late breaking abstract submission

Topic: Late Breaking Abstract

Abs n°:ESPEN12-1876

Abs Title: BENEFICIAL EFFECT OF CLASSICAL JAPANESE FOOD “MISO” ON ENTERAL NUTRITION-RELATED DIARRHEA

M. Kawaguchi ^1,*H. Fujii ¹J. Hirai ¹Y. Hashimoto ¹A. Sumi ¹A. Hara ¹R. Naora ¹A. Kubota ¹S. Yano ¹

¹Nutrition Support Center, Shimane University Faculty of Medicine, Izumo, Japan

Rationale: Severe diarrhea sometimes occurs after enteral nutrition (EN) and is still difficult to treat. “Miso”, which is made from soy beans, rice, salt, and the specific ferment, is commonly used for classical Japanese food like “miso-soup”. We took note of its tuning potential for the digestive function and examined to see the effects of “miso” on EN-related diarrhea and on the acceptance of EN therapy.

Methods: Eighty-eight patients (59 males, 27 females; mean age 71.7 and 75.5, respectively) who had diarrhea (several times or more a day) during EN therapy and did not recover from it by the conventional therapy, agreed to participate in this study. A cup of “miso-soup” (100mL) was infused 2 or 3 times a day just before the EN infusion. Antibiotics were given in 70 patients and GFO (glutamine, fiber, and oligo-saccharide) was supplied in 28 patients. EN had been stopped in 6 patients. The EN access was nasogastric tubing, gastrostomy, and jejunostomy, in 42, 19, and 10 patients, respectively. “Miso-soup” was cooked by boil the 300g of vegetables and fruits in 1L of water for 3 hours and addition of “miso” (8g per 100mL).

Results: The “miso-soup” therapy made it possible to continue EN in 86 patients. Eighty patients tended to recover from diarrhea within 4 days after the “miso-soup” infusion. Twenty patients showed significant recovery among 28 patients, who did not recover from diarrhea by the GFO therapy. Six patients, who had once refused EN therapy, could restart it, because they were cured of diarrhea. It was also noteworthy that no one aggravated diarrhea by “miso-soup” infusion.

Conclusion: The “miso-soup” therapy seems to be more effective than conventional therapies for EN-related diarrhea. Further study is necessary to clarify the benefit of “miso” as a functional food.

Disclosure of Interest: None Declared

Keywords: diarrhea functional food