ESPEN 2012 - Late breaking abstract submission
Topic: Late Breaking Abstract
Abs n°:ESPEN12-1894
Abs Title: COMPARABLE EARLY CHANGES IN GASTROINTESTINAL HORMONES AFTER THE ADMINISTRATION OF SEMI-SOLID DIET IN ELDERLY PEG PATIENTS
S. Haji 1,*M. Fukunaka 2
1surgery, Osaka Saiseikai Nakatsu Hospital, 2surgery, Yamanashi Hospital, Osaka, Japan
Rationale: Changes of gut and pancreatic hormones after the administration of semi-soid formulas through gastrostomy have not been clarified to date in percutaneous endoscopic gastrostomy (PEG) patients. This study aimed to compare the early changes of gastrointestinal hormones involved in insulin secretion after the administration of liquid or semi-solid enteral formulas in elderly PEG patients
Methods: This prospective study investigated 11 elderly subjects undergoing PEG at least 1month before and were stable. Semi-solid diets were prepared with commercial available formulas in Japan; Medief Pushcare (MPC; 300kcal/150g/pack, carbohydrate 42g, viscosity 2000 mPa・s, Ajinomoto co) and PG soft (PGS; 300kcal/200g/pack, carbohydrate 48.2, viscosity 20000 mPa・s, Terumo co. ). Liquid formula was used as control; Medief soy(MS; 300kcal/300ml/pack, carbohydrate 44, viscosity 20 mPa・s, Ajinomoto co). Each of formulas was administered at a bolus of 5-10 minutes per 1 pack through gastrostomy by the washout period of 2 weeks for each patient. Blood glucose, insulin, gastrin, lipase, amylase, and bile acid were measured at 0, 30, 120, 180 minutes after the administration of formulas.
Results: Eligible patients were the mean age of 84.5(75-93) and the number of male was 3 and female was 8. Mean BMI was 19.4 +/- 2.1. Baseline data of 3 different formulas were similar, but blood insulin level at 120 minutes of PGS was significantly lower than those of MPC and MS (PGS; 20.3 +/- 14.1, MPC; 25.4 +/- 17.7, MS 55.1 +/- 37, P<0.05). Blood glucose levels at any point were not different among all patients as well as gastrointestinal hormones evaluated.
Conclusion: The data show that viscosity of enteral formula is associated with an early improvement in glucose tolerance and insulin secretion after the administration of enteral diet compared with liquid and low viscosity diets in elderly patients.
Disclosure of Interest: None Declared
Keywords: semi-solid formula, gastrostomy tube feeding