ESPEN 2012 - Late breaking abstract submission

Topic: Late Breaking Abstract

Abs n°:ESPEN12-1912

Abs Title: USEFULNESS OF ANTIOXIDANT CAPACITY MEASUREMENT USING BAP TEST IN PREDICTING METABOLIC SYNDROME

J. H. Kim ^1,*H. W. Baik ¹J. S. Park ¹S. J. Park ¹E. J. Jang ¹S. W. Park ¹S. J. Kim ¹Y. S. Yoon ²

¹Internal medicine, Bundang Jesaeng General Hospital, Seongnam-si, ²Family Medicine, Ilsan-Paik Hospital, Goyang, Korea, Republic Of

Rationale: Oxidative stress is involved in the development of atherosclerosis and insulin resistance and increases the risk of cardiovascular complication regarding metabolic syndrome (MetS). The aim of this study was to identify the differences of antioxidant capacity according to the presence of MetS, and the relationship between antioxidant capacity and the factors related with MetS.

Methods: The self-reported health of 92 adults classified according to the presence of MetS and MetS-related factors and their antioxidant capacity (measured by BAP test) was compared. Variables were compared by t-test or Χ^2-test. Linear regression analysis was used in order to find the association between reduced antioxidant capacity and the factors of MetS.

Results: The mean BAP of the MetS group was significantly lower than that of the non-MetS group (1,937 vs 2,101 umol/L, p<0.001). The Reduced antioxidant capacity group showed a significant difference in insulin (p=0.033), HOMA-IR (p=0.032), hs-CRP (p=0.020), and adiponectin (p=0.036) compared with the normal antioxidant capacity group. Adiponectin (β±SE; ‐2.66±1.09, p=0.017) and hs‐CRP (β±SE; 0.11±0.05, p=0.033) showed a significant correlation with reduced antioxidant capacity. The odds ratio for BAP (OR 0.5, 95% CI 0.3-0.8, p<0.001), and log HOMA-IR (OR 10.3, 95% CI 1.4-77.4, p<0.001) to MetS showed significant results.

Conclusion: Antioxidant capacity was significantly reduced in the MetS group. Insulin resistance and hs-CRP were increased, and adiponectin was reduced in the Reduced antioxidant group. In particular, the BAP test was proven to be useful as a MetS indicator with HOMA-IR. Therefore, the antioxidant capacity measurement can be used to discover and manage MetS. Further studies regarding the method to enhance antioxidant potential by reducing oxidative stress and the preventive effects on MetS and should be followed.

Disclosure of Interest: None Declared

Keywords: antioxidant capacitymetabolic syndrome