ESPEN 2013 - Late breaking abstract submission

Late Breaking Abstract

ESPEN13-1798

IRON AND ZINC CONTAMINATION IN INDIVIDUAL COMPONENTS USED TO PREPARE PARENTERAL NUTRITION MIXTURES: PRELIMINARY STUDY

A. M. Menendez ^1,*S. Farias ²R. Servant ²Y. Morisio ²Y. Misischia ³A. R. Weisstaub ⁴M. L. Pita Martin de Portela ⁴

¹Farmacia, Belgrano University, ²Analytical Chemistry Department, ³Analitical Chemical Department, CNEA, ⁴Nutrition, Buenos Aires University, Buenos Aires, Argentina

Rationale: To determine iron (Fe) and zinc (Zn) contamination levels in individual components used to prepare parenteral nutrition mixtures (PN) and to compare the true amount given to the patients who would receive PN standard formulas prepared with those components regarding the amounts prescribed by the physician.

Methods: Fe and Zn were determined in  11 commercial products available in Argentina belonging differents labs and lots by Inductively Coupled Plasma- Atomic Emission Spectrometry (Perkin Elmer 5100 DV).

Results: Iron was detected in (μg/mL): Dextrose 50%: 1,12±0,03; Dextrose 70%: 1,32±0,52; Aminoacids 10%: 0,252±0,113; Lipids 20%: 4,58±0,80; Potassium chloride: 0,252±0,113; Sodium chloride 20%: 0,106±0,003; Magnesium sulfate 25%: 0,105±0,000; Sodium glicerophosfate: 2,76±0,48; Calcium gluconate: 2,014±0,267; Zinc sulfate: 0,123±0,004; Manganese sulfate: 1,065; Sterile water: 0,105±0.00. Zn was no detectable in amino acids 10%. Zn, as contaminant, was detected in (μg/mL): Dextrose 50%: 0,32±0,11; Dextrose 70%: 0,80±0,56; Lipids 20%: 3,83±1,29; Potassium chloride: 0,1250±0,0346; Sodium chloride 20%: 0,1088±0,0048; Magnesium sulfate 25%: 0,1200±0,0071; Sodium glicerophosfate: 2,23±0,38; Calcium gluconate: 0,058±0,136; Sterile water: 0,140±0,000.

Conclusion: The adult standard PN mixtures would have more than 2 mg of iron and a zinc excess of 1.2 mg in relation to the prescription. It would be advisable to declare in the products label the content of iron and zinc with the aim to avoid excess which would compromise the evolution of critical patients.

References: Pluhator-Murton M, Fedorak R, Audette R, Marriage B, Yascoff R and Gramlich R JPEN 23:222-7,1999. Menéndez AM, Weisstaub A, Montemerlo H, Rusi F, Guidoni M, Piñeiro A y Pita Martín de Portela M. Nutrición Hospitalaria 2007;22(5): 545-51.

Disclosure of Interest: None Declared

Keywords: Iron, Zinc, contamination, parenteral nutrition