ESPEN 2013 - Late breaking abstract submission
Late Breaking Abstract
ESPEN13-1811
EFFECT OF SERUM ZINC, COPPER AND SELENIUM ON THE CLINICAL OUTCOME IN PATIENTS ON PARENTERAL NUTRITION SUPPORT
A. Young 1V. Mishra 2,*P. Turner 3A. S. Davison 2M. MAHDI 2
1Gastroenterology, 2Clinical Biochemistry and Metabolic Medicine, 3Nutrition and Dietetics, Royal Liverpool and Broadgreen University Hospital NHS Trust, LIVERPOOL, United Kingdom
Rationale: The patients on parenteral nutrition (PN) are usually deficient in trace elements either due to malnutrition or losses. Inflammatory markers also influence the concentration of trace elements in illness. Aim of this study was to assess the effect of serum zinc, copper and selenium concentration on the clinical outcome of patients on PN.
Methods: Serum Zn, Cu, Se levels of 50 patients initiated on PN with underlying gastrointestinal disturbances was studied. Study patients divided into two groups; non-survivors and survivors. The relationship between serum Zn, Cu, Se and inflammatory markers such as CRP, albumin and Pre-albumin was also assessed. Student t test to compare the groups and spearman correlation was used to evaluate the relationships.
Results: Table: Serum Se, Zn, Cu and markers of inflammation in survivors (S) and non-survivors (NS)
Analytes in blood (Reference range) |
Survivors median (SD) |
Non-survivors median (SD) |
P value |
|
Se (0.6-1.5μmol/L) |
0.62(0.2) |
0.43(0.3) |
0.0093* |
|
Zn (12-25 μmol/L) |
8.9(3.9) |
7.6(4.4) |
0.15 |
|
Cu (12-25μmol/L) |
18(3.5) |
14.8(7.0) |
0.15 |
|
CRP (<5mg/L) |
120(1.0) |
138.5(87.1) |
0.92 |
|
Albumin (35-50g/L) |
26(5.8) |
22(7.5) |
0.13 |
|
Pre-albumin (0.2-0.4g/L) |
0.11(0.1) |
0.08(0.1) |
0.97 |
*P value<0.05 is significant
Correlation Analysis: showed a significant positive correlation of Serum Se,Zn and Cu with serum albumin. No significant correlation was seen for all the three trace elements with CRP and Pre-albumin.
Conclusion: Our study suggests that among the three trace elements, only serum Se predicts the clinical outcome in patients on PN. Additionally, the study observed that among the inflammatory markers, serum albumin showed a significant correlation with trace elements. Thus serum albumin influences the concentration of Se, Zn and Cu in blood.
Disclosure of Interest: None Declared
Keywords: None