ESPEN 2013 - Late breaking abstract submission
Late Breaking Abstract
ESPEN13-1835
DOUBLE-BLIND STUDY OF THIAMINE AND COGNITIVE IMPROVEMENT IN CHRONIC HEMODIALYSIS PATIENTS – A PILOT STUDY.
I. P. D. N. N. Maduro 1,*S. P. L. Sousa 1A. R. J. Brandão 1
1Clinical Nutrition, Universidade do Estado do Amazonas, Manaus, Brazil
Rationale: This study proposed to assess cognitive function against the use of thiamine vs placebo in patients undergoing chronic hemodialysis (CHD) because this group commonly present risks of losses of vitamins and other nutrients related to dialysis procedure.1
Methods: in an double-blind study, 32 patients (12 female/ 16 male, 55.8 years ±10.10) submitted to CHD were recruted underwent collection of blood lactate (changed values above 2.0 mMol/L), Mini Mental State Exam (MEEM) (changed values score ³ 24 points). Patients were randomly divided into four groups receiving Thiamine 300 mg, Thiamine 600 mg, Placebo and Control (no vitamin or placebo), during one month. Excluding those using multivitamins, thiamine or cholinergic replacement therapy, patients with respiratory failure, acute coronary insufficiency, unconscious, pregnancy, indigenous ethnicity, younger than 18 years. Blood lactate and MEEM were assessed before and after the study.
Results: Thiamine supplementation (300 or 600 mg) during one month did not interfere with MEEM in groups or within groups. groups before vs after – control group 27.57 ± 1.62 vs 27.71 ± 1.89 (ns); placebo group 26.71 ±1.8 vs 27.0 ±1.73 (ns); Thiamine 300 mg group 27.28 ±1.11 vs 27.86 ±1.57 (ns), Thiamine 600mg group 26.43 ± 0.97 vs 26.86 ± 1.34 (ns).Moreover, lactate values were not altered during the study.
Conclusion: The results showed no cognitive improvement for patients on chronic hemodialysis with 300 or 600 mg of thiamine for 1 month compared with placebo or control groups. Studies with longer duration or the active form of the vitamin should be tested further. This work was supported by Foundation support research in the state of Amazonas (FAPEAM).
References: 1.CHIARELLO, Paula Garcia Chiarello, Maria Terezinha, Hélio Vannucchi. Hyperhomocysteinemia and oxidative stress during dialysis treatment. Renal Failure. 2003; 25(2): 203-213.
Disclosure of Interest: None Declared
Keywords: hemodialysisThiamine