ESPEN 2013 - Late breaking abstract submission

Late Breaking Abstract

ESPEN13-1836

ASSOCIATION OF MICRONUTRIENT INTAKE WITH THE ANGIOGRAPHIC PREVALENCE AND SEVERITY OF CORONARY ARTERY DISEASE

A. Vogel ^1,*A. Teren ^{1 2 3}F. Beutner ^{1 2 3}G. Schuler ^{2 3}C. Helmschrodt ^{1 3}U. Ceglarek ^{1 3}M. Scholz ^{3 4}J. Thiery ^{1 3}

¹Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, ²Department of Internal Medicine/ Cardiology, Heart Center Leipzig, ³LIFE – Leipzig Research Center for Civilization Diseases, University Leipzig, ⁴Institute of Medical Informatics, Statistic and Epidemiology, University Leipzig, Leipzig, Germany

Rationale: Nutrition is considered an important risk factor of coronary artery disease (CAD), thus, the aim of this study was to investigate whether distinct micronutrients and dietary patterns associate with the angiographic presence and severity of CAD.

Methods: The subjects with suspected CAD from the Leipzig (LIFE) Heart Study underwent a standard coronary angiography and answered a validated semi-quantitative Food-Frequency-Questionnaire (FFQ). In all participants, the severity of the coronary atherosclerosis was calculated using the Gensini score.

Results: A total of 1301 participants, median age 62 yrs (IQR: 53- 69 yrs), completed required assessments. The presence of CAD (i.e. at least one coronary stenosis ≥ 50%; n=522, median age 65 yrs; IQR: 56–70 yrs) was significant associated with higher median intake of the amino acids alanine (p=0.022), arginine (p=0.032), aspartic acid  (p=0.041), glycine (p=0.014), histidine (p=0.028), and lysine (p=0.036) as well as with saturated fatty acids (p=0.019), monounsaturated fatty acids (p=0.03), long chain fatty acids (p=0.036) and vitamin A (retinol, p=0.035) when compared with controls (n=779, median age 60 yrs; IQR: 52–69 yrs). Contrary, the intake of provitamin A (β-carotin, p=0.028), galactose (p<0.001) and lactose (p=0.027) was significant lower in subjects with CAD. After adjustment for age, gender, smoking, diabetes, waist-hip-ratio, blood pressure, statin intake, LPa-, LDL- and HDL-level, only retinol showed the positive correlation with Gensini-score (r=0.096/p=0.010).

Conclusion: Our study demonstrates the relationship between nutrition patterns and CAD, highlighting the micronutrients with potential impact on cardiovascular risk. Higher intake of retinol associated independently with more advanced CAD.

Disclosure of Interest: None Declared

Keywords: coronary heart diseasenutrition intake