ESPEN 2013 - Late breaking abstract submission
Late Breaking Abstract
ESPEN13-1807
ALLEVIATING EFFECT OF ACTIVE HEXOSE CORRELATED COMPOUND FOR CHEMOTHERAPY-RELATED SIDE EFFECTS IN UNRESECTABLE PANCREAS CANCER PATIENTS
T. Miura 1,*H. Yanagimoto 2S. Satoi 2H. Toyokawa 2T. Yamamoto 2S. Hirooka 2Y. Matsui 2A.-H. Kwon 2
1Scientific Affairs Division, Amino Up Chemical Co., Ltd., Sapporo, 2Surgery, Kansai Medical University, Osaka, Japan
Rationale: Recently, advancement of cancer chemotherapy obviously contributes to high response rate; on the other hand, it is possible to lower the QOL of patients because of its severe and frequent side effects. The present study was conducted to determine whether AHCC, a functional food extracted from cultured basidiomycete, possesses the potential to attenuate side effects in unresectable pancreas cancer patients receiving chemotherapy.
Methods: Unresectable pancreas cancer patients undergoing the first gemcitabine treatment (GEM) were divided into 2 groups with and without AHCC. The subjects of AHCC group ingested 6.0 g of AHCC between meals every day for 2 months. Hematological and non-hematological toxicity were measured before and after the supplementation. The therapeutic efficiency was evaluated in terms of response rate and survival duration.
Results: The subject number of AHCC group and no supplementation (control) group was 35 and 40, respectively. There was no subject who discontinued the AHCC consumption due to its side effects. No significant difference was observed in blood tests and backgrounds between both groups before GEM. All subjects significantly suffered bone marrow suppression, liver impairment, and C-reactive protein (CRP) elevation. CRP elevation of AHCC group was less than that of control group following GEM administration. The taste disorder caused by GEM was improved in AHCC group (16% vs. 56%, p<0.05). AHCC induced the significantly high serum albumin value. There was no alteration in the response rate, but the disease control rate was significantly higher in AHCC group. AHCC group tended to show good result in the survival duration although there was no significant difference.
Conclusion: AHCC is effective to reduce the side effects associated with chemotherapy, suggesting that AHCC might contribute to maintaining the QOL of patients.
Disclosure of Interest: T. Miura Other: an employee of Amino Up Chemical Co., Ltd.H. Yanagimoto Grant / Research Support from: Amino Up Chemical Co., Ltd.S. Satoi : None DeclaredH. Toyokawa : None DeclaredT. Yamamoto : None DeclaredS. Hirooka : None DeclaredY. Matsui : None DeclaredA.-H. Kwon Grant / Research Support from: Amino Up Chemical Co., Ltd.
Keywords: chemotherapyside effect