ESPEN 2013 - Late breaking abstract submission

Late Breaking Abstract

ESPEN13-1828

EFFECT OF ENZYME-TREATED ASPARAGUS (ETAS) ON THE STRESS RESPONSE SUBSTANCE IN THE CLINICAL TRIAL

H. Waki ¹S. Miyazaki ²T. Miura ³K. Uebaba ¹T. Hisajima ^1,*

¹Faculty of Health Care, Teikyo Heisei University, ²Faculty of Health Care, Teikyo Heisei University, Tokyo, ³Amino Up Chemical Co.,Ltd., Sapporo, Japan

Rationale:  The aim of this study was to examine the effectiveness to the stress response substance in stressful stimuli of ETAS.

Methods:  The randomized, double-blind, placebo-controlled, cross-over trial was undertaken with healthy volunteers (n=25). ETAS (150 mg/day) or placebo was scheduled, each of 28 days, with a 14-days wash-out. The examination was done in order of the questionnaire survey of condition, sitting position, and mental arithmetic for psychological stress. In the mental arithmetic, the autonomic-nervous functions were measured by the heart rate variability analyses using an active orthostatic test, and were analyzed in real time with heart rate variability wave-analysis software. After the mental arithmetic test, blood and saliva were extracted, and POMS was performed. The levels of serum cortisol and plasma catecholamine were measured with the extracted blood, and the concentration of sIgA and cortisol in saliva were analyzed. 

Results:  The main results of Day 28 to Day 0 in the ETAS group were: 1) In the questionnaire survey of condition, the items of “Feel tired”, “Hard to get up” and “Feel heavy” showed the effective results. 2) The number of answers and correct answers of the mental arithmetic increased significantly. 3) After the mental arithmetic, two items of "depression - falling" and "fatigue" in POMS showed the effective results. 4) After the mental arithmetic, the correction value of sIgA level in saliva (μg/mg) of increased significantly (Day 0: 208.11±168.20; Day 28:298.66±154.71). On the other hands, the levels of cortisol and catecholamine did not changed.

Conclusion:  When the ETAS intake for 28 days raised the results of mental arithmetic as dysphoria stimulation, increased the levels of sIgA promoting a stress response. These data suggest that ETAS intake may reduce a tired feeling in daily living and have beneficial effects in the response to dysphoria stress.

Disclosure of Interest: H. Waki: None DeclaredS. Miyazaki: None DeclaredT. Miura: None DeclaredK. Uebaba: None DeclaredT. Hisajima Grant / Research Support from: Amino Up Chemical Co.,Ltd.

Keywords: Psychological stress, Autonomic-nervous functions, Secretory IgA