ESPEN 2013 - Late breaking abstract submission

Late Breaking Abstract

ESPEN13-1839

SERUM STATUS OF HEPCIDIN AND IRON TURN OVER AFTER SURGERY

T. Nagahama ^1,*

¹Surgery, TOSHIMA HOSPITAL, Tokyo, Japan

Rationale: Hepcidin is known as protein regulating iron homeostasis but one of acute phase protein. In this study we have measured the serum hepcidin level and iron turn over after gastrointestinal surgery to evaluate the effect of perioperative iron supply.

Methods:  11 patients receiving gastric resection or colon-rectal resection were enrolled in this study and they were randomly assigned into two groups. 8 patients (Group A) received TPN solution and other 3 patients (Group B) received same solution combined with trace element solution including 35 micro molar of iron per day. Transfusion was not carried out during postoperative period. TPN solution was given from the day after surgery and maintained for 8 days. Oral intake was not permitted during 5 days except water. Serum iron studies, red cell indices, hemogram, C-reactive protein (CRP),and serum hepcidin were measured on preoperatively (pre-op), and day1, day5, day9 (PO1,PO5,PO9) postoperatively. 

Results:  Serum hepcidin level on Pre, PO1, PO5, PO9 were 26.4,129,51,48, in Group A and 1.3,102,51,51, in Group B. Serum Fe level were 91,15,39,45 in Group A and 59,33,31,55 in Group B. Ferritin level were 190,178,306,236 in Group A and 51,124,197,171 in Group B. CRP were 0.5,5.7,1.9, 2.5 in Group A and 0.1,11.5,5.9,4.7 in Group B respectively. Those results were not statsistically different between Group A and Group B.

Conclusion: Our result proved that serum hepcidin rose during postoperative period and is co-related with those of CRP. Serum Fe decreased on PO1 and increased gradually on PO5 and PO9. Those results were similar in Group A and Group B. Those results suggested that at early post-operative condition, iron supplementation did not improve iron turnover or storage. Elevation of hepcidin may result impairment of iron utilization after surgery. In short term iron supplementation may not be necessary.

Disclosure of Interest: None Declared

Keywords: HepcidinSurgery