ESPEN 2013 - Late breaking abstract submission
Late Breaking Abstract
ESPEN13-1845
THE CHANGES OF ANTIOXIDANT CAPACITY AFTER HIP FRACTURE IN KOREAN ELDERLY PATIENTS
J. H. Kang 1,*H. K. Chung 2H. W. BAIK 3
1Clinical Nutrition Department, Daejin Medical Center, Bundang Jesaeng General Hospital, Kyunggido, 2Severance institute for vascular and metabolic research, Yonsei University, Seoul, 3Internal Medicine, Daejin Medical Center, Bundang Jesaeng General Hospital, Kyunggido, Korea, Republic Of
Rationale: Hip fracture is related with high morbidity and mortality, and is major factor to cause healthcare cost in elderly patients. Hip fracture patients undergo hypermetabolism with oxidative stress after fracture. Degree of oxidative stress is important factor to determine their clinical outcomes. The aim of this study is to examine the changes of various antioxidant parameters after fracture in Korean elderly patients.
Methods: Patients aged over 65years who require surgery for a femoral neck or intertrochanteric fractures were included.We were estimated energy and protein requirement and examined change of energy and protein intake according to the duration. Data on blood levels of antioxidant markers such as superoxide dismutase(SOD),Glutathione peroxidase(GPX), catalase,Ferric reducing antioxidant power(FRAP),serum zinc,whole blood selenium were also analyzed.
Results: The mean age of 85patients was 81.3±7.0years and BMI was 21.2±3.7kg/m2. 89.4% was female. The means need of calorie and protein of patients were 1,506.5±140.1kcal, 51.3±9.8g. There were significantly differences means intake of calorie and protein between on admission and 14days after surgery(admission:1,142±492.3kcal,protein 46.9±24.8g, 14days after surgery:1,595.0±562.0kcal,64.1±25.1g,p=0.000). There were significantly differences antioxidant markers and the means levels were as follows; admission:SOD 67.7±11.2%, FRAP 283.5±89.0μ㏖, 7days after surgery:SOD 71.2±10.9% and FRAP 261.0±91.3μ㏖, 14days after surgery:SOD 66.0±11.5%,p=0.001, FRAP 308.4±98.2μ㏖,p=0.046.
Conclusion: The results of this study imply that some antioxidant capacity decreased on admission and 7days after hip fracture surgery, and improved on 14days after surgery in Korean elderly patients. Therefore, aggressive treatment such as antioxidant supplement or immune enhanced oral nutritional supplementation may be considered before 14days after surgery to alleviate oxidative stress.
Disclosure of Interest: None Declared
Keywords: antioxidant capacity, elderly, hip fracture