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 THE ANTI-TNF SUCCESS STORY AND THE NEW CHALLENGES AHEAD Jochen Salfeld      
O01TREATMENT WITH HETERODIMERIC IL-15 SHAPES THE CYTOKINE AND CHEMOKINE MILIEU OF THE TUMOR, PROMOTING TUMOR INFILTRATION BY CYTOTOXIC LYMPHOCYTES: A GENERAL METHOD FOR LYMPHOCYTE ENTRY IN TUMORS Cristina Bergamaschi, Bethany Nagy, Shawn M. Jensen, Konstantinos Dimas, Dimitris Stellas, Bernard A. Fox, Barbara K. Felber, George N. Pavlakis Oral communication28.10.201809:45Grand Ballroom APlenary 1: Immunoregulation IPlenary
O02REGULATION OF NOVEL PATTERN RECOGNITION RECEPTOR SIGNALING AND IFN INDUCTION BY UNANCHORED K48-LINKED POLYUBIQUITIN CHAINS Adam Hage, Preeti Bharaj, Ricardo Rajsbaum Oral communication28.10.201810:00Grand Ballroom APlenary 1: Immunoregulation IPlenary
O03DELINEATION OF THE INFLAMMATORY PATHWAY BEHIND PROTEASOME-ASSOCIATED AUTOINFLAMMATORY SYNDROME Sophia Davidson, Fiona Moghaddas, Paul Baker, Dale Calleja, Bejamin T Kile, Raphaela T Goldbach-Mansky, Seth L Masters Oral communication28.10.201810:15Grand Ballroom APlenary 1: Immunoregulation IPlenary
O04DI- AND TRIMERIC BIOLOGICAL SWITCHES MADE OF NANOBODY-CYTOKINE RECEPTOR FUSION PROTEINS SIMULATE NATURAL SIGNAL TRANSDUCTION Erika Engelowski, Philipp Lang, Jürgen Scheller Oral communication28.10.201812:15Grand Ballroom ASymposium 1: Innate Sensing and SignalingSymposium
O05A METABOLITE-TRIGGERED TUFT CELL-ILC2 CIRCUIT DRIVES SMALL INTESTINAL REMODELING Christoph Schneider, Claire E O’Leary, Jakob von Moltke, Hong-Erh Liang, Qi Yan Ang, Peter J Turnbaugh, Sridhar Radhakrishnan, Michael Pellizzon, Averil Ma, Richard M Locksley Oral communication28.10.201812:25Grand Ballroom ASymposium 1: Innate Sensing and SignalingSymposium
O06TYPE I INTERFERON SIGNALING ATTENUATES REGULATORY T CELL FUNCTION IN VIRAL INFECTION AND IN THE TUMOR MICROENVIRONMENT Arunakumar Gangaplara, Craig Martens, Eric Dahlstrom, Amina Metidji, Ameya S Gokhale, Deborah D Glass, Maria-Lopez Ocasio, Rachel Baur, Kishore Kanakabandi, Stephen F Porcella, Ethan M Shevach Oral communication28.10.201812:15Grand Ballroom BSymposium 2: Antiviral responsesSymposium
O07GAP-JUNCTION DEPENDENT TRANS-ACTIVATION OF HUMAN MONOCYTES BY CGAMP. Genevieve Pepin, Dominic De Nardo, Michael Gantier Oral communication28.10.201812:25Grand Ballroom BSymposium 2: Antiviral responsesSymposium
O08GSDMD IS CRITICAL FOR AUTOINFLAMMATORY PATHOLOGY IN A MOUSE MODEL OF FAMILIAL MEDITERRANEAN FEVER Apurva Kanneganti, Mohamed Lamkanfi Oral communication28.10.201815:40Grand Ballroom ASymposium 3: Inflammasomes, Interferons and beyond Symposium
O09THE AIM2 INNATE IMMUNE DNA SENSOR FACILITATES STAT3-DRIVEN GASTRIC TUMORIGENESIS. Virginie Deswaerte, Brendan J. Jenkins Oral communication28.10.201815:50Grand Ballroom ASymposium 3: Inflammasomes, Interferons and beyond Symposium
O10MODULATION OF INTERLEUKIN-22 ALLEVIATE RESPIRATORY VIRAL INFECTION BY PROMOTING EPITHELIAL INTRINSIC TYPE I INTERFERON RESPONSE Ran Wang, Steven Taylor, Md Moniruzzaman, Kuan Yau Wong, Alice C-H Chen, Yang Xi, Jennifer Simpson, John Upham, Kirsten Spann, Michael McGuckin, Simon Phipps, Sumaira Hasnain Oral communication28.10.201815:40Grand Ballroom BSymposium 4: Infection and Inflammation in the LungSymposium
O11ADAM17/IL-6 TRANS-SIGNALLING AXIS: A PROMISING THERAPEUTIC TARGET FOR LUNG ADENOCARCINOMA Mohamed I Saad, Sultan Alhayyani, Louise McLeod, Liang Yu, Christoph Garbers, Saleela Ruwanpura, Irit Sagi, Stefan Rose-John, Brendan Jenkins Oral communication28.10.201815:50Grand Ballroom BSymposium 4: Infection and Inflammation in the LungSymposium
O12DECOUPLING IL-6 BIOLOGICAL EFFECTS USING PROTEIN ENGINEERING Jonathan Martinez-Fabregas, Stephan Wilmes, Ignacio Moraga Gonzalez Oral communication28.10.201818:10Grand Ballroom ASymposium 5: Cytokines in Neuronal InflammationSymposium
O13DEMYSTIFYING THE MECHANISM OF MITOCHONDRIAL STAT3 ACTIVITY. Daniel Gough, Dilanka Fernando, Daniel Garama Oral communication28.10.201818:20Grand Ballroom ASymposium 5: Cytokines in Neuronal InflammationSymposium
O14CRITICAL ROLE OF IFNS IN GASTRO-INTESTINAL INJURY REPAIR Constance McElrath, Jian-Da Lin, Vanessa Espinosa, Jianya Peng, Raghavendra Sridhar, Hsiang-Chi Tseng, Sergey Smirnov, Heidi Risman, Marvin Sandoval, Mark Galan, Amariliz Rivera, Joan Durbin, Sergei Kotenko Oral communication28.10.201818:10Grand Ballroom BSymposium 6: Intestinal HomeostasisSymposium
O15NLRP1 INFLAMMASOME EXACERBATES INFLAMMATORY BOWEL DISEASE THROUGH IL-18 PRODUCTION AND DYSBIOSIS OF BUTYRATE PRODUCING COMMENSAL CLOSTRIDIALES Chien-Hsiung Yu, Hazel Tye, Lisa A Simms, Cassandra R Harapas, Jocelyn S Penington, Adele Preaudet, Stephen A Wilcox, Anthony T Papenfuss, Tracy Putoczki, Graham L Radford-Smith, Seth L. Masters Oral communication28.10.201818:20Grand Ballroom BSymposium 6: Intestinal HomeostasisSymposium
O16TYPE I INTERFERONS REGULATE B CELL DEVELOPMENT AND DIFFERENTIATION Munir Akkaya, Billur Akkaya, Arunakumar Gangaplara, Alexander S Roesler, Brandon P Theall, Susan K Pierce Oral communication29.10.201810:20Grand Ballroom A-BPlenary 2: Advances in Pathogenic Th17 axis of evilPlenary
O17ALLERGIC INFLAMMATORY MEMORY OF TYPE 2 CYTOKINES IN HUMAN RESPIRATORY EPITHELIAL PROGENITOR CELLS Jose Ordovas-Montanes, Daniel F Dwyer, Sarah K Nyquist, Kathleen M Buchheit, Marko Vukovic, Neil Bhattacharyya, Tanya M Laidlaw, Joshua A Boyce, Nora A Barrett, Alex K Shalek Oral communication29.10.201812:15Grand Ballroom ASymposium 7: Type II ImmunitySymposium
O18TISSUE SIGNALS IMPRINT ILC2 TRANSCRIPTIONAL IDENTITY AND PREEMPTIVE FUNCTION Steven Van Dyken, Roberto Ricardo-Gonzalez, Christoph Schneider, Jinwoo Lee, Jesse Nussbaum, Ari Molofsky, Richard Locksley Oral communication29.10.201812:25Grand Ballroom ASymposium 7: Type II ImmunitySymposium
O19STAT3 SUPPRESSES PRIMARY TUMOUR GROWTH, BUT INCREASES METASTASIS IN MYC-DRIVEN SMALL CELL LUNG CANCER Aleks Camille Guanizo, Jasmine Chen, W. Samantha N Jayasekara, D. Neil Watkins, Daniel J Gough Oral communication29.10.201812:15Grand Ballroom BSymposium 8: Innate Cytokines and CancerSymposium
O20SUCCESSFUL ANTI-PD-1 CANCER IMMUNOTHERAPY REQUIRES T CELL-DENDRITIC CELL CROSSTALK INVOLVING IFN-𝛾 AND IL-12 Christopher S Garris, Sean P Arlauckas, Ralph Weissleder, Mikael J Pittet Oral communication29.10.201812:25Grand Ballroom BSymposium 8: Innate Cytokines and CancerSymposium
O21INTERLEUKIN-11 SIGNALING INDUCES A UNIQUE PATHOGENIC CD4+ T HELPER-17 CELL POPULATION Ka Yee Fung, Adele Preaudet, Paul Nguyen, Charlotte Burstroem, Kirsten Edwards, Nick Wilson , Tracy Putoczki Oral communication29.10.201815:40Grand Ballroom ASymposium 9: Immunoregulation IISymposium
O22THE STROMAL TISSUE COMPARTMENT AS AN ORCHESTRATOR OF IL-6-DRIVEN ANTI-MICROBIAL HOST DEFENCE Javier Uceda, David Millrine, Anna Cardus, Robert Andrews, Christopher Rice, Victoria Tyrrell, Ceri Fielding, Barbara Szomolay, Barbara Coles, Chantal Colmont, Nicholas Topley, Philip Taylor, Nigel Williams, Gareth W. Jones, Simon A. Jones Oral communication29.10.201815:50Grand Ballroom ASymposium 9: Immunoregulation IISymposium
O23IFN-LAMBDA FACILITATES PROTECTIVE T CELL IMMUNITY BY MODULATION OF MIGRATORY DENDRITIC CELL FUNCTION DURING INFLUENZA VIRUS INFECTION Emily A Hemann, Richard Green, Ryan A Langlois, Ram Savan, Michael Gale Oral communication29.10.201815:40Grand Ballroom BSymposium 10: Type III and other IFNsSymposium
O24INACTIVATION OF TYPE I INTERFERON RESPONSES IN THE TUMOR MICROENVIRONMENT TRIGGERS THE STROMAGENIC SWITCH AND DESMOPLASIA Christina Cho, Riddhita Mukherjee, Jun Gui, Kanstantsin V. Katlinski, Yuliya V Katlinskaya, Serge Y Fuchs Oral communication29.10.201815:50Grand Ballroom BSymposium 10: Type III and other IFNsSymposium
O25TYPE I INTERFERON SENSING UNLOCKS DORMANT ADIPOCYTE INFLAMMATORY POTENTIAL Senad Divanovic, Calvin Chan, Monica Cappelletti, Maria Moreno-Fernandez, Traci Stankiewicz, Rebekah Karns, Rajib Mukherjee, Matthew Weirauch, Michael Helmrath, Thomas Inge Oral communication30.10.201810:10Grand Ballroom ASymposium 13: Philip I. Marcus SymposiumSymposium
O26THE LONG NON-CODING RNA LUCAT1 TRANSCRIPTIONALLY REGULATES TYPE-I INTERFERON RESPONSES Shiuli Agarwal, Sreya Ghosh, Pranitha Vangala, Emiliano Ricci, Daniel Caffrey, Manuel Garber, Kate Fitzgerald Oral communication30.10.201810:20Grand Ballroom ASymposium 13: Philip I. Marcus SymposiumSymposium
O27A LONG NONCODING RNA ATTENUATES DENDRITIC CELL CYTOKINE PRODUCTION AND DECREASES AUTOIMMUNE DISEASE SUSCEPTIBILITY Tom Brodnicki, Michelle Ashton, Colleen Elso, Edward Chu, Sharon Ford, Natalie Payne, May Alsayb, Helen Thomas, Stuart Mannering, Tom Kay, Tony Papenfuss, Esteban Gurzov, Richard Kitching, Claude Bernard, Hans Acha-Orbea, Grant Morahan, Ken Shortman, Meredith O'Keeffe Oral communication30.10.201810:10Grand Ballroom BSymposium 14: Dermal Responses, CytokinesSymposium
O28AIM2-DEFICIENT DENDRITIC CELL VACCINE FACILITATES ADOPTIVE T-CELL THERAPY AND ANTI-PD-1 IMMUNOTHERAPY VIA THE ACTIVATION OF STING-TYPE I IFN SIGNALING Keitaro Fukuda, Rebecca L Riding, John E Harris Oral communication30.10.201810:20Grand Ballroom BSymposium 14: Dermal Responses, CytokinesSymposium
O29THE EXPANDING FUNCTIONS OF THE INFLAMMASOME COMPLEXES Vijay Rathinam Oral communication30.10.201811:00Grand Ballroom ASymposium 15: Inflammasome and IL1 Family members IISymposium
O30THE NLRC4 INFLAMMASOME REQUIRES IRF8-DEPENDENT PRODUCTION OF NAIPS Rajendra Karki, Ein Lee, Thirumala-Devi Kanneganti Oral communication30.10.201812:15Grand Ballroom ASymposium 15: Inflammasome and IL1 Family members IISymposium
O31GERM-CELL SPECIFIC INFLAMMASOME COMPONENT NLRP14 NEGATIVELY REGULATES CYTOSOLIC NUCLEIC ACID SENSING TO PROMOTE FERTILIZATION Sagi Shapira, Takayuki Abe, Albert Lee, Raul Rabadan Oral communication30.10.201812:25Grand Ballroom ASymposium 15: Inflammasome and IL1 Family members IISymposium
O32"THE MULTIFACETED M152 PROTEIN SELECTIVELY MODULATES STING-DEPENDENT SIGNALING TO ENHANCE MURINE CYTOMEGALOVIRUS REPLICATION" Markus Stempel, Baca Chan, Vanda Juranic Lisnic, Soren Paludan, Stipan Jonjic, Niels Lemmermann, Melanie M Brinkmann Oral communication30.10.201812:15Grand Ballroom BSymposium 16: Infection and ImmunitySymposium
O33ACTIVATION OF MITOCHONDRIAL APOPTOTIC SIGNALING TRIGGERS NLRP3 INFLAMMASOME ACTIVATION James E. Vince, Dominic De Nardo, Wenqing Gao, Angelina Vince, Cathrine Hall, Kate McArthur, Swarna Vijayaraj, Lisa M Lindqvist, Jennifer M Chambers, Mark A Rizzacasa, John Silke, Seth L Masters, Guillaume Lessene, Daniel H Gray, Benjamin T Kile, Feng Shao, Kate E Lawlor Oral communication30.10.201812:25Grand Ballroom BSymposium 16: Infection and ImmunitySymposium
O34IL-38 RESTRICTS ANTI-TUMOR IMMUNITY BY LIMITING IL-17 PRODUCTION FROM GAMMA-DELTA T CELLS THROUGH IL1RAPL1 Javier Mora, Yingying Han, Bernhard Bruene, Andreas Weigert Oral communication30.10.201813:00Grand Ballroom ATrainee workshop AWorkshop
O35SIGNIFICANT REDUCTION OF TUMOR GROWTH AND METASTASIS BY INTRATUMOR TREATMENT OF A SHRNA TARGETING IL-17RA IN A MURINE B16F10 MELANOMA MODEL Ya-Shan Chen, Chao-Lin Liu, Hui-Shan Chen, Meng-Hua Lee, Chia-Rui Shen Oral communication30.10.201813:10Grand Ballroom ATrainee workshop AWorkshop
O36MITOCHONDRIAL DOUBLE STRANDED RNA TRIGGERS ANTIVIRAL SIGNALLING IN HUMANS Ashish Dhir Oral communication30.10.201813:20Grand Ballroom ATrainee workshop AWorkshop
O37ELF5 REGULATED INTERFERON SIGNALING IN TRIPLE NEGATIVE BREAST CANCER Rumela Chakrabarti, Snahlata Singh Oral communication30.10.201813:30Grand Ballroom ATrainee workshop AWorkshop
O38MYELOID P38 MAPK PROMOTES TUMORIGENESIS BY SUPPRESSING CYTOTOXIC T CELL RECRUITMENT Min-Kyung Choo, Jin Mo Park Oral communication30.10.201813:40Grand Ballroom ATrainee workshop AWorkshop
O39A PROGRAMMABLE SIGNALING COMPLEX CONTROLS CELL FATE DECISIONS UPON TOLL-LIKE RECEPTOR ACTIVATION Yunhao Tan, Jonathan Kagan Oral communication30.10.201813:00Grand Ballroom BTrainee workshop BWorkshop
O40A NEW ANTIVIRAL ISG TDRD7 INHIBITS CELLULAR AUTOPHAGY TO CONTROL VIRUS REPLICATION Saurabh Chattopadhyay, Gayatri Subramanian, Karan Chawla, Ritu Chakravarti Oral communication30.10.201813:10Grand Ballroom BTrainee workshop BWorkshop
O41NEW TRICKS FOR AN OLD DOG: NON-CANONICAL STAT3 MEDIATES TLR4 MITOCHONDRIAL REPROGRAMMING AND INFLAMMATION Ashley Scott Mansell, Daniel Gough Oral communication30.10.201813:20Grand Ballroom BTrainee workshop BWorkshop
O42THE MOONLIGHTING PROTEIN 14-3-3 ETA CONTROLS MDA5 ACTIVATION AND THE MDA5-DEPENDENT ANTIVIRAL INNATE IMMUNITY Jih-pu Lin, Helene Minyi Liu Oral communication30.10.201813:30Grand Ballroom BTrainee workshop BWorkshop
O43IMPORTANT DIFFERENCES IN THE IFN-I RESPONSE TO DNA AND RNA VIRUS PARTICLES David Hare, Karen Mossman Oral communication30.10.201813:40Grand Ballroom BTrainee workshop BWorkshop
O44IL-27P28 IS AN ANTAGONIST OF B CELL RESPONSE DURING TOXOPLASMOSIS Jeongho Park, Jonathan H DeLong, Christoph Konradt, Elia D. Tait Wojno, Christopher A Hunter Oral communication30.10.201813:00Grand ballroom CTrainee workshop CWorkshop
O45IL-36 CYTOKINES ALTER THE COMPOSITION OF THE INTESTINAL MICROBIOME TO PROTECT AGAINST OBESITY AND METABOLIC DYSFUNCTION Eirini Giannoudaki, Yasmina Esther Hernandez-Santana, Kelly Mulfaul, Sarah L. Doyle, Emily Hams, Padraic G. Fallon, Arimin Mat, Donal O’Shea, Manfred Kopf , Andrew E. Hogan, Patrick T. Walsh Oral communication30.10.201813:10Grand ballroom CTrainee workshop CWorkshop
O46PLACENTA-SPECIFIC 8 SUPPRESSES INTERFERON GAMMA PRODUCTION BY TH1 CELLS Chris D Slade, Katie L Reagin, Kim D Klonowski, Wendy T Watford Oral communication30.10.201813:20Grand ballroom CTrainee workshop CWorkshop
O47EPIGENETIC LANDSCAPE OF FOXP3 ENHANCER SITES DURING THYMIC FOXP3+ TREG DEVELOPMENT OF CNS0- AND CNS3-DEFICIENT MICE Ryoji Kawakami, Yohko Kitagawa, Keiji Hirota, Hitomi Watanabe, Gen Kondo, Kelvin Chen, Naganari Ohkura, Shimon Sakaguchi Oral communication30.10.201813:30Grand ballroom CTrainee workshop CWorkshop
O48HIPPO/MST SIGNALING COUPLES METABOLIC STATE AND FUNCTION OF CD8A+ DENDRITIC CELLS FOR CYTOTOXIC T-CELL PRIMING Xingrong Du, Jing Wen, Yanyan Wang, Peer Karmaus, Alireza Khatamian, Haiyan Tan, Yuxin Li, Cliff Guy, Thanh-Long M Nguyen, Yogesh Dhungana, Geoffrey Neale, Junmin Peng, Jiyang Yu, Hongbo Chi Oral communication30.10.201813:40Grand ballroom CTrainee workshop CWorkshop
O49CYTOKINE AND TRANSCRIPTIONAL REGULATION OF STEM CELL-LIKE CD8 T CELLS Tuoqi Wu, Pamela Schwartzberg Oral communication30.10.201815:15Grand Ballroom ASymposium 17: T cell regulation in CancerSymposium
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